Silica particles

  • are available in the size range of 10 nm to 1.5 µm with a density of 2.0 g/cm³ as monodisperse and nonporous particles,

  • have broader size distributions in the area of the porous silica particles with adjusted diameters between 3 and 20 microns and a density of 1.8 g/cm³,

  • have a hydrophilic surface with terminal Si-OH-bonds,

  • are produced by hydrolysis of orthosilicates and related compounds,

  • are extremely stable in organic solvents and aqueous buffers,

  • particles ≥ 200 nm can easily be separated by simple sedimentation or centrifugation,

  • particles < 200 nm can be separated by ultracentrifugation or washed by SEC or ultrafiltration/dialysis,

  • are designed with the surface functionalities OH (plain), NH2, COOH, CHO, SO3H, SH, N-hydroxysuccinimide (NHS) or epoxy for the covalent binding of proteins, antibodies or other molecules,

  • are available with covalently bound proteins (avidin, streptavidin, protein A, albumin),

  • can be provided with covalently bound antibodies on request,

  • can be offered with the nickel(II) chelator nitrilotriacetic acid (NTA) or ready to use with the corresponding nickel complex (Ni-NTA) for the binding of histidine labeled proteins,

  • are also suitable for the complexation of metal ions with covalently bound chelators on the particle surface (EDTA, DTPA),

  • are provided with gold dotation (Other metal dotations (e.g. Pt, Pd, Ag) are available on request),

  • can be modified with other inorganic structures (co-titania or co-alumina),

  • are available with various hydrophobic/ organic surfaces (trimethylsilyl (TMS), octadecyl (C18)).